/* ========== GLOBAL STYLES ========== */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
    background: linear-gradient(135deg, #6db4a6 0%, #5a9b8c 100%);
    min-height: 100vh;
    color: #333;
    padding-bottom: 80px;
}

.container {
    max-width: 1600px;
    margin: 0 auto;
    padding: 20px;
}

/* Navigation Bar */
.navbar {
    background: rgba(255, 255, 255, 0.95);
    border-radius: 15px;
    padding: 15px 30px;
    margin-bottom: 30px;
    box-shadow: 0 10px 30px rgba(0,0,0,0.1);
    display: flex;
    justify-content: space-between;
    align-items: center;
    backdrop-filter: blur(10px);
}

.nav-brand {
    font-size: 1.5rem;
    font-weight: 700;
    color: #5a9b8c;
    text-decoration: none;
}

.nav-links {
    display: flex;
    gap: 20px;
    list-style: none;
}

.nav-link {
    color: #333;
    text-decoration: none;
    padding: 10px 20px;
    border-radius: 10px;
    transition: all 0.3s ease;
    font-weight: 600;
    cursor: pointer;
}

.nav-link:hover, .nav-link.active {
    background: linear-gradient(135deg, #6db4a6, #5a9b8c);
    color: white;
    transform: translateY(-2px);
}

/* Header */
.header {
    text-align: center;
    margin-bottom: 40px;
    color: white;
}

.header h1 {
    font-size: 3rem;
    font-weight: 700;
    margin-bottom: 10px;
    text-shadow: 2px 2px 4px rgba(0,0,0,0.2);
}

.header p {
    font-size: 1.2rem;
    opacity: 0.95;
    margin-bottom: 10px;
}

.github-link {
    margin-top: 15px;
}

.github-link a {
    background: rgba(255, 255, 255, 0.2);
    color: white;
    padding: 8px 16px;
    border-radius: 20px;
    text-decoration: none;
    font-weight: 600;
    font-size: 0.9rem;
    transition: all 0.3s ease;
    backdrop-filter: blur(10px);
}

.github-link a:hover {
    background: rgba(255, 255, 255, 0.3);
    transform: translateY(-2px);
}

/* Information Cards */
.info-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 15px;
    margin-bottom: 25px;
}

.info-card {
    background: rgba(255, 255, 255, 0.95);
    border-radius: 12px;
    padding: 15px;
    box-shadow: 0 8px 20px rgba(0,0,0,0.08);
    border-left: 4px solid #6db4a6;
    min-height: auto;
}

.info-card h4 {
    color: #5a9b8c;
    margin-bottom: 8px;
    font-size: 1.1rem;
    display: flex;
    align-items: center;
    gap: 8px;
}

.info-content {
    color: #555;
    font-size: 0.9rem;
    line-height: 1.4;
}

.info-content strong {
    color: #2c3e50;
    font-weight: 600;
}

/* Module Navigation */
.module-nav {
    background: rgba(255, 255, 255, 0.95);
    border-radius: 15px;
    padding: 20px 30px;
    margin-bottom: 30px;
    box-shadow: 0 10px 30px rgba(0,0,0,0.1);
    backdrop-filter: blur(10px);
}

.module-nav h3 {
    color: #5a9b8c;
    margin-bottom: 15px;
    text-align: center;
}

.module-tabs {
    display: flex;
    justify-content: center;
    gap: 10px;
    flex-wrap: wrap;
}

.module-tab {
    background: #f8f9fa;
    color: #666;
    padding: 12px 24px;
    border-radius: 10px;
    cursor: pointer;
    transition: all 0.3s ease;
    font-weight: 600;
    border: 2px solid transparent;
}

.module-tab:hover {
    background: #e9ecef;
    transform: translateY(-2px);
}

.module-tab.active {
    background: linear-gradient(135deg, #6db4a6, #5a9b8c);
    color: white;
    transform: translateY(-2px);
    box-shadow: 0 5px 15px rgba(109, 180, 166, 0.4);
}

/* Module Content */
.module-content {
    display: none;
}

.module-content.active {
    display: block;
}

/* Controls */
.controls {
    background: rgba(255, 255, 255, 0.95);
    border-radius: 15px;
    padding: 20px;
    margin-bottom: 30px;
    box-shadow: 0 10px 30px rgba(0,0,0,0.1);
}

.controls h3 {
    color: #5a9b8c;
    margin-bottom: 15px;
}

.controls-row {
    display: flex;
    gap: 30px;
    align-items: center;
    flex-wrap: wrap;
    margin-bottom: 15px;
}

.control-group {
    display: flex;
    gap: 15px;
    align-items: center;
}

.control-group label {
    font-weight: 600;
    min-width: 120px;
}

select, input {
    padding: 8px 12px;
    border: 2px solid #ddd;
    border-radius: 8px;
    font-size: 14px;
    transition: border-color 0.3s ease;
    min-width: 200px;
}

select:focus, input:focus {
    outline: none;
    border-color: #6db4a6;
}

/* Gene Input Container */
.gene-input-container {
    position: relative;
}

#gene-suggestions {
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    background: white;
    border: 2px solid #6db4a6;
    border-top: none;
    border-radius: 0 0 8px 8px;
    max-height: 200px;
    overflow-y: auto;
    z-index: 1000;
    display: none;
}

.suggestion-item {
    padding: 8px 12px;
    cursor: pointer;
    border-bottom: 1px solid #eee;
}

.suggestion-item:hover, .suggestion-item.selected {
    background: #f0f8ff;
}

button {
    background: linear-gradient(135deg, #6db4a6, #5a9b8c);
    color: white;
    border: none;
    padding: 10px 20px;
    border-radius: 8px;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s ease;
    min-width: 160px;
}

button:hover {
    transform: translateY(-2px);
    box-shadow: 0 5px 15px rgba(109, 180, 166, 0.4);
}

button:disabled {
    opacity: 0.8;
    cursor: not-allowed;
    transform: none;
    box-shadow: none;
}

.button-loading {
    background: linear-gradient(135deg, #ffa726, #ff9800) !important;
}

.button-success {
    background: linear-gradient(135deg, #66bb6a, #4caf50) !important;
}

.button-error {
    background: linear-gradient(135deg, #ef5350, #f44336) !important;
}

.button-hint-container {
    display: flex;
    gap: 15px;
    align-items: center;
}

.gene-hint {
    background: #ffebee;
    color: #c62828;
    padding: 8px 12px;
    border-radius: 6px;
    font-size: 0.9rem;
    border-left: 3px solid #c62828;
    display: none;
}

.gene-hint.show {
    display: block;
}

.controls-help {
    margin-top: 10px;
    padding: 8px 12px;
    background: #f8f9fa;
    border-radius: 6px;
    border-left: 3px solid #6db4a6;
}

.controls-help small {
    color: #666;
    font-size: 0.85rem;
}

.controls-help strong {
    color: #5a9b8c;
}

/* Analysis Grid - Updated for better responsiveness */
.analysis-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 20px;
    margin-bottom: 30px;
    max-width: 1400px;
    margin-left: auto;
    margin-right: auto;
}

.analysis-card {
    background: rgba(255, 255, 255, 0.95);
    border-radius: 20px;
    padding: 20px;
    box-shadow: 0 20px 40px rgba(0,0,0,0.1);
    transition: all 0.3s ease;
    display: flex;
    flex-direction: column;
}

.analysis-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 25px 50px rgba(0,0,0,0.15);
}

.analysis-card h3 {
    color: #5a9b8c;
    margin-bottom: 15px;
    font-size: 1.3rem;
    display: flex;
    align-items: center;
    gap: 10px;
    flex-shrink: 0;
}

/* Visualization containers */
.viz-container {
    width: 100%;
    height: 450px;
    border-radius: 10px;
    background: #f8f9fa;
    position: relative;
    overflow: hidden;
    flex: 1;
}

.viz-container > div {
    width: 100% !important;
    height: 100% !important;
    display: block !important;
    visibility: visible !important;
}

.viz-container svg {
    width: 100% !important;
    height: 100% !important;
    display: block !important;
}

.viz-container .plotly-graph-div {
    width: 100% !important;
    height: 100% !important;
}

.viz-placeholder {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    text-align: center;
    color: #666;
    z-index: 1;
}

.loading-spinner {
    border: 3px solid #f3f3f3;
    border-top: 3px solid #6db4a6;
    border-radius: 50%;
    width: 40px;
    height: 40px;
    animation: spin 1s linear infinite;
    margin: 0 auto 10px;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

.error-message {
    background: #ffebee;
    color: #c62828;
    padding: 15px;
    border-radius: 8px;
    margin: 10px 0;
    border-left: 4px solid #c62828;
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    width: 90%;
    text-align: center;
    z-index: 10;
}

/* DEG and Pathway Analysis */
.deg-analysis-section, .pathway-table-section {
    margin-bottom: 30px;
}

.deg-controls, .pathway-controls {
    display: flex;
    gap: 15px;
    align-items: center;
    margin-bottom: 20px;
    flex-wrap: wrap;
    background: #f8f9fa;
    padding: 15px;
    border-radius: 8px;
}

.deg-table-container {
    width: 100%;
    min-height: 300px;
    border-radius: 10px;
    background: #f8f9fa;
    position: relative;
    overflow: auto;
    max-height: 600px;
}

.deg-table {
    width: 100%;
    border-collapse: collapse;
    background: white;
    border-radius: 8px;
    overflow: hidden;
    box-shadow: 0 2px 10px rgba(0,0,0,0.1);
}

.deg-table th {
    background: linear-gradient(135deg, #6db4a6, #5a9b8c);
    color: white;
    padding: 12px 15px;
    text-align: left;
    font-weight: 600;
    font-size: 0.9rem;
    position: sticky;
    top: 0;
    z-index: 10;
}

.deg-table td {
    padding: 10px 15px;
    border-bottom: 1px solid #eee;
    font-size: 0.9rem;
}

.deg-table tr:hover {
    background-color: #f8f9fa;
}

.deg-table tr:last-child td {
    border-bottom: none;
}

.gene-name, .pathway-name {
    font-weight: 600;
    color: #2c3e50;
}

.log2fc-positive, .nes-positive {
    color: #e74c3c;
    font-weight: 600;
}

.log2fc-negative, .nes-negative {
    color: #3498db;
    font-weight: 600;
}

.p-value {
    font-family: 'Courier New', monospace;
    font-size: 0.8rem;
    color: #666;
}

.deg-summary {
    background: #e8f5e8;
    padding: 10px 15px;
    border-radius: 6px;
    margin-bottom: 15px;
    border-left: 4px solid #2ecc71;
}

.deg-summary h4 {
    color: #2ecc71;
    margin-bottom: 5px;
    font-size: 1rem;
}

.deg-summary p {
    color: #666;
    font-size: 0.9rem;
    margin: 0;
}

/* Trajectory and Interaction Modules */
.trajectory-container, .interaction-container {
    text-align: center;
    padding: 20px;
}

.trajectory-container img, .interaction-container img {
    max-width: 100%;
    height: auto;
    border-radius: 10px;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.analysis-description {
    margin-top: 15px;
    padding: 15px;
    background: #f8f9fa;
    border-radius: 8px;
    border-left: 4px solid #6db4a6;
    text-align: left;
}

.analysis-description h4 {
    color: #5a9b8c;
    margin-bottom: 10px;
}

.analysis-description p {
    color: #666;
    margin: 0;
    line-height: 1.6;
}

/* Cell-Cell Interaction Plot */
#interaction-plot {
    height: 1200px !important;
}

/* Footer */
.footer {
    position: fixed;
    bottom: 0;
    left: 0;
    right: 0;
    background: rgba(0, 0, 0, 0.8);
    color: white;
    text-align: center;
    padding: 15px 20px;
    font-size: 0.9rem;
    backdrop-filter: blur(10px);
    z-index: 1000;
}

.footer a {
    color: #6db4a6;
    text-decoration: none;
    font-weight: 600;
    transition: all 0.3s ease;
}

.footer a:hover {
    color: #7bc4b6;
    text-decoration: underline;
}

/* Mobile Responsive */
@media (max-width: 1200px) {
    .analysis-grid {
        grid-template-columns: 1fr;
        max-width: 800px;
    }
    
    .viz-container {
        height: 400px;
    }
}

@media (max-width: 768px) {
    .navbar {
        flex-direction: column;
        gap: 15px;
    }

    .nav-links {
        gap: 10px;
    }

    .header h1 {
        font-size: 2rem;
    }

    .controls-row {
        flex-direction: column;
        align-items: flex-start;
        gap: 15px;
    }

    .control-group {
        flex-direction: column;
        align-items: flex-start;
        width: 100%;
    }

    .control-group label {
        min-width: auto;
    }

    select, input {
        width: 100%;
        min-width: auto;
    }
    
    .viz-container {
        height: 350px;
    }

    .button-hint-container {
        flex-direction: column;
        align-items: flex-start;
        gap: 10px;
    }

    .module-tabs {
        flex-direction: column;
        gap: 10px;
    }

    .module-tab {
        text-align: center;
    }

    .info-grid {
        grid-template-columns: 1fr;
        gap: 12px;
    }
    
    .info-card {
        padding: 12px;
    }

    .deg-controls, .pathway-controls {
        flex-direction: column;
        gap: 10px;
    }

    .analysis-grid {
        grid-template-columns: 1fr;
        gap: 15px;
    }

    #interaction-plot {
        height: 800px !important;
    }
}